From the Literature: Understanding Science

Immunotherapy

Immunotherapy

2 articles

CAR-T Therapy Can Be Merged With Antibody-Drug Conjugates
2026-02-11•Immunotherapy

CAR-T Therapy Can Be Merged With Antibody-Drug Conjugates

Solid tumors have resisted both CAR-T therapy and antibody-drug conjugates for different reasons. This study collapses that divide, engineering CAR-T cells that deliver chemotherapy directly within the tumor microenvironment.

CAR-T |Antibody-Drug Conjugates
Metabolic Fitness as a Limiting Factor in CAR-NK Therapy
2025-12-30•Immunotherapy

Metabolic Fitness as a Limiting Factor in CAR-NK Therapy

Why do CAR-NK therapies work… until they don’t? This post looks at a paper by the Rezvani Lab that argues relapse isn’t just the tumor getting smarter, but immune cells slowly running out of energy.

CAR-NK |Metabolism